• Association between Alcohol Consumption and Body Composition in Russian Adults and Patients Treated for Alcohol-Related Disorders: The Know Your Heart Cross-Sectional Study 

      Mitkin, Nikita Andreevich; Unguryanu, Tatiana Nikolaevna; Malyutina, Sofia; Kudryavtsev, Alexander V (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-07)
      There is conflicting evidence about the association between alcohol consumption and body composition (BC). We aimed to investigate this association in Russian adults. The study population included 2357 residents of Arkhangelsk aged 35–69 years, and 272 in-patients treated for alcohol problems (narcological patients) who participated in the Know Your Heart (KYH) cross-sectional study in 2015–2017. ...
    • Between-study differences in grip strength: a comparison of Norwegian and Russian adults aged 40-69 years 

      Cooper, Rachel; Shkolnikov, Vladimir M.; Kudryavtsev, Alexander; Malyutina, Sofia; Ryabikov, Andrew; Hopstock, Laila Arnesdatter; Johansson, Jonas; Cook, Sarah Anne; Leon, David; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-03)
      Background - Identifying individuals with low grip strength is an initial step in many operational definitions of sarcopenia. As evidence indicates that contemporaneous Russian populations may have lower mean levels of grip strength than other populations in northern Europe, we aimed to: compare grip strength in Russian and Norwegian populations by age and sex; investigate whether height, body mass ...
    • C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk 

      Mirolyubova, Olga A.; Kudryavtsev, Alexander V.; Semchyugova, Elvira; Malyutina, Sofia; Ryabikov, Andrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09)
      <p><i>Цель - </i>Оценка связи высокочувствительного С-реактивного белка (вчСРБ) с кардиометаболическими и эхокардиографическими (ЭхоКГ) индикаторами сердечной недостаточности (СН) среди взрослого населения Северного региона России. <p><i>Материал и методы - </i>Поперечное исследование «Узнай свое сердце» проведено в 2015–2017 гг. на случайной выборке общего населения г. Архангельска в возрасте 35–69 ...
    • Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway 

      Cook, Sarah; Solbu, Marit Dahl; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila Arnesdatter; Kholmatova, Kamila Kahramonzhonovna; Kudryavtsev, Alexander V; Leon, David A.; Malyutina, Sofia; Ryabikov, Andrew; Williamson, Elizabeth; Nitsch, Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.<p> <p>Methods - We compared age- and sex-standardised prevalence of ...
    • Effect of adiposity on differences in carotid plaque burden in studies conducted in Norway and Russia: a cross-sectional analysis of two populations at very different risk of cardiovascular mortality 

      Imahori, Yume; Frost, Chris; Mathiesen, Ellisiv B.; Ryabikov, Andrey; Kudryavtsev, Alexander V; Malyutina, Sofia; Kornev, Michael; Hughes, Alun D; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      <i>Objectives</i> - Large differences exist in the burden of cardiovascular disease (CVD) between Russia and Western European countries including Norway. Obesity prevalence may contribute to the differences. We investigated whether difference in the level of adiposity, assessed using body mass index and waist-to-hip ratio(WHR), could explain intercountry differences in the burden of carotid plaque, ...
    • External validation of a deep learning electrocardiogram algorithm to detect ventricular dysfunction 

      Attia, Itzhak Zachi; Tseng, Andrew S.; Benavente, Ernest Diez; Medina-Inojosa, Jose R.; Clark, Taane; Malyutina, Sofia; Kapa, Suraj; Schirmer, Henrik; Kudryavtsev, Alexander V; Noseworthy, Peter A.; Carter, Rickey E.; Ryabikov, Andrey; Perel, Pablo; Friedman, Paul A.; Leon, David A.; Lopez-Jimenez, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-02)
      Objective - To validate a novel artificial-intelligence electrocardiogram algorithm (AI-ECG) to detect left ventricular systolic dysfunction (LVSD) in an external population.<p> <p>Background - LVSD, even when asymptomatic, confers increased morbidity and mortality. We recently derived AI-ECG to detect LVSD using ECGs based on a large sample of patients treated at the Mayo Clinic.<p> <p>Methods ...
    • Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. 

      Magnussen, Christina; Ojeda, Francisco M.; Leong, Darryl P.; Alegre-Diaz, Jesus; Amouyel, Philippe; Aviles-Santa, Larissa; De Bacquer, Dirk; Ballantyne, Christie M.; Bernabé-Ortiz, Antonio; Bobak, Martin; Brenner, Hermann; Carrillo-Larco, Rodrigo M.; De Lemos, James; Dobson, Annette; Dörr, Marcus; Donfrancesco, Chiara; Drygas, Wojciech; Dullaart, Robin P.; Engström, Gunnar; Ferrario, Marco M.; Ferrières, Jean; De Gaetano, Giovanni; Goldbourt, Uri; Gonzalez, Clicerio; Grassi, Guido; Hodge, Allison M.; Hveem, Kristian; Iacoviello, Licia; Ikram, M. Kamran; Irazola, Vilma; Jobe, Modou; Jousilahti, Pekka; Kaleebu, Pontiano; Kavousi, Maryam; Kee, Frank; Khalili, Davood; Koenig, Wolfgang; Kontsevaya, Anna; Kuulasmaa, Kari; Lackner, Karl J.; Leistner, David M.; Lind, Lars; Linneberg, Allan; Lorenz, Thiess; Lyngbakken, Magnus Nakrem; Malekzadeh, Reza; Malyutina, Sofia; Mathiesen, Ellisiv B.; Melander, Olle; Metspalu, Andres; Miranda, J. Jaime; Moitry, Marie; Mugisha, Joseph; Nalini, Mahdi; Nambi, Vijay; Ninomiya, Toshiharu; Oppermann, Karen; D'Orsi, Eleonora; Pająk, Andrzej; Palmieri, Luigi; Panagiotakos, Demosthenes; Perianayagam, Arokiasamy; Peters, Annette; Poustchi, Hossein; Prentice, Andrew M.; Prescott, Eva; Risérus, Ulf; Salomaa, Veikko; Sans, Susana; Sakata, Satoko; Schöttker, Ben; Schutte, Aletta E.; Sepanlou, Sadaf G.; Sharma, Sanjib Kumar; Shaw, Jonathan E.; Simons, Leon A.; Söderberg, Stefan; Tamosiunas, Abdonas; Thorand, Barbara; Tunstall-Pedoe, Hugh; Twerenbold, Raphael; Vanuzzo, Diego; Veronesi, Giovanni; Waibel, Julia; Wannamethee, S. Goya; Watanabe, Masafumi; Wild, Philipp S.; Yao, Yao; Zeng, Yi; Ziegler, Andreas; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      BACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.<p> <p>METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic ...
    • Hazardous alcohol consumption and problem drinking in Norwegian and Russian women and men: The Tromsø Study 2015–2016 and the Know Your Heart study 2015–2018 

      Hopstock, Laila Arnesdatter; Kudryavtsev, Alexander V; Malyutina, Sofia; Cook, Sarah (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-30)
      Aim: Harmful use of alcohol is a worldwide public health concern. Cultural differences may affect responses to questions on alcohol problems, making international comparisons difficult. We aimed to compare self-reported alcohol consumption and problem drinking between Norwegian and Russian populations.<p> <p>Methods: We used data from women and men aged 40–69 years participating in the Tromsø ...
    • Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function 

      Iakunchykova, Olena; Schirmer, Henrik; Leong, Darryl; Malyutina, Sofia; Ryabikov, Andrey; Averina, Maria; Kudryavtsev, Alexander V; Kornev, Mikhail; Voronina, Ekaterina; Paramonov, Andrey; Wilsgaard, Tom; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
      Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p> <p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
    • Influence of hypertension on systolic and diastolic left ventricular function including segmental strain and strain rate 

      Kornev, Mikhail; Hatice, Akay Caglayan; Kudryavtsev, Alexander V; Malyutina, Sofia; Ryabikov, Andrew; Schirmer, Henrik; Rösner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)
      Background - Left ventricular (LV) systolic and diastolic functions are important cardiovascular risk predictors in patients with hypertension. However, data on segmental, layer-specific strain, and diastolic strain rates in these patients are limited. The aim of this study was to investigate segmental two-dimensional strain rate imaging (SRI)-derived parameters to characterize LV systolic and ...
    • Long-term trends in blood pressure and hypertension in Russia: an analysis of data from 14 health surveys conducted in 1975–2017 

      Churilova, Elena; Shkolnikov, Vladimir M.; Shalnova, Svetlana A.; Kudryavtsev, Alexander V; Malyutina, Sofia; Nilssen, Odd-Ragnar; Laatikainen, Tiina; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
      Background - Hypertension is recognized as an important contributor to high cardiovascular mortality in Russia. A comprehensive analysis of data from Russian studies that measured blood pressure in population-based samples has not been previously undertaken. This study aims to identify trends and patterns in mean blood pressure and the prevalence of hypertension in Russia over the most recent ...
    • Novel approach to artefact detection and the definition of normal ranges of segmental strain and strain-rate values 

      Kornev, Mikhail; Caglayan, Hatice Aklay; Kudryavtsev, Alexander V; Malyutina, Sofia; Ryabikov, Andrew; Stylidis, Michael; Schirmer, Henrik; Rosner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)
      Aims - Strain artefacts are known to hamper the correct interpretation of segmental strain and strain-rate (S/SR). Defining the normal ranges of myocardial segmental deformation is important in clinical studies and routine echocardiographic practice. In order to define artefact-free normal ranges for segmental longitudinal S/SR parameters, we investigated the extent to which different types of ...
    • Obesity Prevalence and Associated Socio-Demographic Characteristics and Health Behaviors in Russia and Norway 

      Kholmatova, Kamila Kahramonzhonovna; Krettek, Alexandra; Leon, David A; Malyutina, Sofia; Cook, Sarah; Hopstock, Laila Arnesdatter; Løvsletten, Ola; Kudryavtsev, Alexander V (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-01)
      Associations between obesity and socio-demographic and behavioral characteristics vary between populations. Exploring such differences should throw light on factors related to obesity. We examined associations between general obesity (GO, defined by body mass index) and abdominal obesity (AO, defined by waist-to-hip ratio) and sex, age, socio-economic characteristics (education, financial ...
    • Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: Comparison between population-based studies in Russia and Norway 

      Cook, Sarah Anne; Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Bates, Katie; Iakunchykova, Olena; Kontsevaya, Anna; McKee, Martin; Schirmer, Henrik; Voevoda, Michael; Kudryavtsev, Alexander V; Malyutina, Sofia; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-19)
      <i>Background</i> - Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes.<p><p> <i>Methods</i> - The study population was adults aged 40–69 years reporting ...
    • Prevalence of symptoms, ever having received a diagnosis and treatment of depression and anxiety, and associations with health service use amongst the general population in two Russian cities 

      Cook, Sarah Anne; Kudryavtsev, Alexander V; Bobrova, Natalia; Saburova, Lyudmila; Denisova, Diana; Malyutina, Sofia; Lewis, Glyn; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)
      <i>Background</i> - Little is known about the burden of common mental disorders in Russia despite high levels of suicide and alcohol-related mortality. Here we investigated levels of symptoms, self-reports of ever having received a diagnosis and treatment of anxiety and depression in two Russian cities.<p> <p><i>Methods</i> - The study population was men and women aged 35–69 years old participating ...
    • Primary care use and cardiovascular disease risk in Russian 40–69 year olds: a cross-sectional study 

      Petersen, Jakob; Kontsevaya, Anna V.; McKee, Martin; Richardson, E.; Cook, Sarah Anne; Malyutina, Sofia; Kudryavtsev, Alexander V; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
      <i>Background</i> - The Russian Federation has very high cardiovascular disease (CVD) mortality rates compared with countries of similar economic development. This cross-sectional study compares the characteristics of CVD-free participants with and without recent primary care contact to ascertain their CVD risk and health status.<br><br> <i>Methods</i> - A total of 2774 participants aged 40–69 ...
    • Quantification of the smoking-associated cancer risk with rate advancement periods: Meta-analysis of individual participant data from cohorts of the CHANCES consortium 

      Ordóñez-Mena, José Manuel; Schöttker, Ben; Mons, Ute; Jenab, Mazda; Freisling, Heinz; Bueno-De-Mesquita, Hendrik Bastiaan; O'Doherty, Mark G.; Scott, Angela; Kee, Frank; Stricker, Bruno H.; Hofman, Albert; de Keyser, Catherine E.; Ruiter, Rikje; Söderberg, Stefan; Jousilahti, Pekka; Kuulasmaa, Kari; Freedman, Neal D.; Wilsgaard, Tom; de Groot, Lisette C.P.G.M.; Kampman, Ellen; Håkansson, Niclas; Orsini, Nicola; Wolk, Alicja; Nilsson, Lena Maria; Tjønneland, Anne; Pająk, Andrzej; Malyutina, Sofia; Kúbinová, Růžena; Tamosiunas, Abdonas; Bobak, Martin; Katsoulis, Michail; Orfanos, Philippos; Boffetta, Paolo; Trichopoulou, Antonia; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)
      Background:<br> Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking ...
    • Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway 

      Trias-Llimós, Sergi; Pennells, Lisa; Tverdal, Aage; Kudryavtsev, Alexander V; Malyutina, Sofia; Hopstock, Laila Arnesdatter; Iakunchykova, Olena; Nikitin, Yuri; Magnus, Per; Kaptoge, Stephen; Di Angelantonio, Emanuele; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
      Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing so, applying it to the substantial CVD mortality gap between Russia and Norway using survey data in three cities and mortality risks from the Emerging Risk Factor Collaboration. ...
    • The relation of gender role attitudes with depression and generalised anxiety disorder in two Russian cities 

      Jaehn, Phillip; Bobrova, Natalia; Saburova, Lyudmila; Kudryavtsev, Alexander V; Malyutina, Sofia; Cook, Sarah Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-08)
      <i>Background</i> - Reported traditional gender role attitudes (GRAs) have been related to worse mental health in western countries. This study examined the link of GRAs with symptoms of depression and generalised anxiety disorder (GAD) in two Russian cities.<br><br> <i>Methods</i> - We used interview data from the cross-sectional Know Your Heart Study conducted among 5099 adults aged 35-69 in ...
    • Socio-demographic, behavioural and psycho-social factors associated with depression in two Russian cities 

      Cook, Sarah; Saburova, Lyudmila; Bobrova, Natalia; Avdeeva, Ekaterina; Malyutina, Sofia; Kudryavtsev, Alexander V; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-04)
      Background - Russia has a high burden of suicide and alcohol-attributable mortality. However there have been few studies of the epidemiology of depression.<p> <p>Methods - The study population was 5077 men and women aged 35-69 years from a cross-sectional population based survey in the cities of Arkhangelsk and Novosibirsk (2015-17). Moderate depression was defined as Patient Health Questionnaire-9 ...